Rho-associated kinase plays a role in rabbit urethral smooth muscle
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چکیده
1 contraction, but not via enhanced myosin light chain phosphorylation 2 3 Michael P. WALSH, Keith THORNBURY, William C. COLE, Gerard SERGEANT, Mark 4 HOLLYWOOD and Noel McHALE 5 6 Smooth Muscle Research Group and Department of Biochemistry and Molecular Biology, Faculty of 7 Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada, Smooth Muscle Research Centre, 8 Dundalk Institute of Technology, Dundalk, Co. Louth, Ireland, and Smooth Muscle Research Group 9 and Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Calgary, 10 Alberta T2N 4N1, Canada 11 12 Address for reprint requests and other correspondence: M. P. Walsh, Department of Biochemistry 13 and Molecular Biology, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada 14 (email [email protected]). 15 16 Running title: Smooth muscle contraction without an increase in myosin phosphorylation 17 18 19 20 ABSTRACT 21
منابع مشابه
Rho-associated kinase plays a role in rabbit urethral smooth muscle contraction, but not via enhanced myosin light chain phosphorylation.
The involvement of Rho-associated kinase (ROK) in activation of rabbit urethral smooth muscle contraction was investigated by examining the effects of two structurally distinct inhibitors of ROK, Y27632 and H1152, on the contractile response to electric field stimulation, membrane depolarization with KCl, and α1-adrenoceptor stimulation with phenylephrine. Both compounds inhibited contractions ...
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